Evolutionary dynamics of bovine coronaviruses: natural selection pattern of the spike gene implies adaptive evolution of the strains.
Identifieur interne : 001943 ( Main/Exploration ); précédent : 001942; suivant : 001944Evolutionary dynamics of bovine coronaviruses: natural selection pattern of the spike gene implies adaptive evolution of the strains.
Auteurs : Mehdi R M. Bidokhti [Suède] ; Madeleine Tr Vén [Suède] ; Neel K. Krishna [États-Unis] ; Muhammad Munir [Suède] ; Sándor Belák [Suède] ; Stefan Alenius [Suède] ; Martí Cortey [Royaume-Uni]Source :
- The Journal of general virology [ 1465-2099 ] ; 2013.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Analyse de regroupements, Analyse de séquence d'ADN, Animaux, Bovins, Coronavirus bovin (), Coronavirus bovin (génétique), Coronavirus bovin (isolement et purification), Danemark (épidémiologie), Données de séquences moléculaires, Flambées de maladies, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (virologie), Maladies des bovins (virologie), Phylogénie, Protéines de l'enveloppe virale (génétique), Similitude de séquences d'acides aminés, Suède (épidémiologie), Sélection génétique, Évolution moléculaire.
- MESH :
- génétique : ARN viral, Coronavirus bovin, Glycoprotéines membranaires, Protéines de l'enveloppe virale.
- isolement et purification : Coronavirus bovin.
- médecine vétérinaire : Infections à coronavirus.
- virologie : Infections à coronavirus, Maladies des bovins.
- épidémiologie : Danemark, Suède.
- Analyse de regroupements, Analyse de séquence d'ADN, Animaux, Bovins, Coronavirus bovin, Données de séquences moléculaires, Flambées de maladies, Glycoprotéine de spicule des coronavirus, Phylogénie, Similitude de séquences d'acides aminés, Sélection génétique, Évolution moléculaire.
- Wicri :
English descriptors
- KwdEn :
- Animals, Cattle, Cattle Diseases (virology), Cluster Analysis, Coronavirus Infections (veterinary), Coronavirus Infections (virology), Coronavirus, Bovine (classification), Coronavirus, Bovine (genetics), Coronavirus, Bovine (isolation & purification), Denmark (epidemiology), Disease Outbreaks, Evolution, Molecular, Membrane Glycoproteins (genetics), Molecular Sequence Data, Phylogeny, RNA, Viral (genetics), Selection, Genetic, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Spike Glycoprotein, Coronavirus, Sweden (epidemiology), Viral Envelope Proteins (genetics).
- MESH :
- chemical , genetics : Membrane Glycoproteins, RNA, Viral, Viral Envelope Proteins.
- geographic , epidemiology : Denmark, Sweden.
- classification : Coronavirus, Bovine.
- genetics : Coronavirus, Bovine.
- isolation & purification : Coronavirus, Bovine.
- veterinary : Coronavirus Infections.
- virology : Cattle Diseases, Coronavirus Infections.
- Animals, Cattle, Cluster Analysis, Disease Outbreaks, Evolution, Molecular, Molecular Sequence Data, Phylogeny, Selection, Genetic, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Spike Glycoprotein, Coronavirus.
Abstract
Coronaviruses demonstrate great potential for interspecies transmission, including zoonotic outbreaks. Although bovine coronavirus (BCoV) strains are frequently circulating in cattle farms worldwide, causing both enteric and respiratory disease, little is known about their genomic evolution. We sequenced and analysed the full-length spike (S) protein gene of 33 BCoV strains from dairy and feedlot farms collected during outbreaks that occurred from 2002 to 2010 in Sweden and Denmark. Amino acid identities were >97 % for the BCoV strains analysed in this work. These strains formed a clade together with Italian BCoV strains and were highly similar to human enteric coronavirus HECV-4408/US/94. A high similarity was observed between BCoV, canine respiratory coronavirus (CRCoV) and human coronavirus OC43 (HCoV-OC43). Molecular clock analysis of the S gene sequences estimated BCoV and CRCoV diverged from a common ancestor in 1951, while the time of divergence from a common ancestor of BCoV and HCoV-OC43 was estimated to be 1899. BCoV strains showed the lowest similarity to equine coronavirus, placing the date of divergence at the end of the eighteenth century. Two strongly positive selection sites were detected along the receptor-binding subunit of the S protein gene: spanning amino acid residues 109-131 and 495-527. By contrast, the fusion subunit was observed to be under negative selection. The selection pattern along the S glycoprotein implies adaptive evolution of BCoVs, suggesting a successful mechanism for BCoV to continuously circulate among cattle and other ruminants without disappearance.
DOI: 10.1099/vir.0.054940-0
PubMed: 23804565
Affiliations:
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Le document en format XML
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regroupements</term><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Bovins</term><term>Coronavirus bovin</term><term>Données de séquences moléculaires</term><term>Flambées de maladies</term><term>Glycoprotéine de spicule des coronavirus</term><term>Phylogénie</term><term>Similitude de séquences d'acides aminés</term><term>Sélection génétique</term><term>Évolution moléculaire</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Danemark</term><term>Suède</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronaviruses demonstrate great potential for interspecies transmission, including zoonotic outbreaks. Although bovine coronavirus (BCoV) strains are frequently circulating in cattle farms worldwide, causing both enteric and respiratory disease, little is known about their genomic evolution. We sequenced and analysed the full-length spike (S) protein gene of 33 BCoV strains from dairy and feedlot farms collected during outbreaks that occurred from 2002 to 2010 in Sweden and Denmark. Amino acid identities were >97 % for the BCoV strains analysed in this work. These strains formed a clade together with Italian BCoV strains and were highly similar to human enteric coronavirus HECV-4408/US/94. A high similarity was observed between BCoV, canine respiratory coronavirus (CRCoV) and human coronavirus OC43 (HCoV-OC43). Molecular clock analysis of the S gene sequences estimated BCoV and CRCoV diverged from a common ancestor in 1951, while the time of divergence from a common ancestor of BCoV and HCoV-OC43 was estimated to be 1899. BCoV strains showed the lowest similarity to equine coronavirus, placing the date of divergence at the end of the eighteenth century. Two strongly positive selection sites were detected along the receptor-binding subunit of the S protein gene: spanning amino acid residues 109-131 and 495-527. By contrast, the fusion subunit was observed to be under negative selection. The selection pattern along the S glycoprotein implies adaptive evolution of BCoVs, suggesting a successful mechanism for BCoV to continuously circulate among cattle and other ruminants without disappearance. </div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Virginie</li></region></list><tree><country name="Suède"><noRegion><name sortKey="Bidokhti, Mehdi R M" sort="Bidokhti, Mehdi R M" uniqKey="Bidokhti M" first="Mehdi R M" last="Bidokhti">Mehdi R M. Bidokhti</name></noRegion><name sortKey="Alenius, Stefan" sort="Alenius, Stefan" uniqKey="Alenius S" first="Stefan" last="Alenius">Stefan Alenius</name><name sortKey="Belak, Sandor" sort="Belak, Sandor" uniqKey="Belak S" first="Sándor" last="Belák">Sándor Belák</name><name sortKey="Munir, Muhammad" sort="Munir, Muhammad" uniqKey="Munir M" first="Muhammad" last="Munir">Muhammad Munir</name><name sortKey="Tr Ven, Madeleine" sort="Tr Ven, Madeleine" uniqKey="Tr Ven M" first="Madeleine" last="Tr Vén">Madeleine Tr Vén</name></country><country name="États-Unis"><region name="Virginie"><name sortKey="Krishna, Neel K" sort="Krishna, Neel K" uniqKey="Krishna N" first="Neel K" last="Krishna">Neel K. Krishna</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Cortey, Marti" sort="Cortey, Marti" uniqKey="Cortey M" first="Martí" last="Cortey">Martí Cortey</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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